Top SNPs (Pmeta-value≤1×10−5) associated with AL from the meta-analysis in the three Asian cohorts.

aMA, minor allele.bMAF, minor allele frequency in each cohort.cGWAS cohorts. SCES - Singapore Chinese Eye Study; SCORM - Singapore Cohort study of the Risk factors for Myopia; SiMES - Singapore Malay Eye Study.dβ, coefficient of linear regression; s.e., standard error for coefficient β. Association between each genetic marker and AL was examined using linear regression, adjusted for age, gender, height and level of education. The effect sizes denote changes in millimeter of AL per each additional copy of the minor allele.ePhet, P-value for heterogeneity by Cochran's Q test across three study cohorts.