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Bulk RNAseq Analysis of Murine Thoracic Aortas with Tsc1+/+ and Tsc1-/- Smooth Muscle Cells

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NIAID Data Ecosystem2026-03-11 收录
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We characterized the transcriptomic effects of chronic mTOR activation in aortic SMCs using a conditional genetic model to delete Tsc1 under control of a smooth muscle-specific Myh11 promoter Myh11-CreERT2.mT/mG (Tsc1+/+) and Tsc1fl/fl.Myh11-CreERT2.mT/mG (Tsc1−/−) male mice were treated with tamoxifen at 1.5 wk and the thoracic aortas were analyzed by bulk RNAseq at 24 wk.

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2019-08-26
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