Loss of NADPH oxidase activity in phagocytes leads to altered cellular responses and exaggerated inflammation in Chronic Granulomatous Disease (CGD). We sought to assess the effects of Nox2 absence on

NIAID Data Ecosystem20

O2- production by B lymphocytes lacking the respiratory burst oxidase subunit p47phox after transfection with an expression vector containing a p47phox cDNA.

慢性肉芽肿病

呼吸爆发氧化酶功能恢复

The respiratory burst oxidase of phagocytes and B lymphocytes is a complicated enzyme that catalyzes the one-electron reduction of oxygen by NADPH. It is responsible for the O2- production that occurs

PubMed Central1992-11-01 更新00

Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat.

慢性肉芽肿病

二核苷酸缺失突变

Chronic granulomatous disease (CGD) is a rare inherited condition rendering neutrophils incapable of killing invading pathogens. This condition is due to the failure of a multicomponent microbicidal o

PubMed Central1991-04-01 更新20

Data_Sheet_1_Hematopoietic Cell Transplantation for Chronic Granulomatous Disease in Japan.zip

造血细胞移植

慢性肉芽肿病

Hematopoietic cell transplantation (HCT) is established as a curative treatment for severe chronic granulomatous disease (CGD). However, outcomes of HCT for CGD in Japan had not been precisely reporte

NIAID Data Ecosystem10

Distribution of different subtypes of CGD according to sex.

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