Recruitment of caspase-8 and -10 to FADD complex

Caspase-8 (CASP8) and caspase-10 (CASP10) are involved in RIG-I/MDA5-dependent antiviral immune responses. Caspase-8/10 activation contributes to NF-kB activation in response to viral dsRNA.<br>Caspase-8/10 are synthesized as zymogens (procaspases), containing a large N-terminal prodomain with two death effector domains (DED), and a C-terminal catalytic subunit composed of small and a large domain separated by a smaller linker region. FADD plays a crucial role in the recruitment and activation of procaspase-8/10. The two DED domains of procaspase-8/10 interacts with DED domain of FADD.

Caspase-8（CASP8）及caspase-10（CASP10）参与RIG-I/MDA5依赖性的抗病毒免疫反应。Caspase-8/10的激活有助于NF-kB在病毒双链RNA刺激下的激活。Caspase-8/10作为酶原（前Caspase）合成，包含一个大型N端前结构域及两个死亡效应域（DED），以及由小、大两个结构域通过较小的连接区域分隔的C端催化亚基。FADD在procaspase-8/10的募集和激活过程中发挥着至关重要的作用。procaspase-8/10的两个DED结构域与FADD的DED结构域相互作用。