MicroRNA-21-5p participate in IgA nephropathy by driving T helper cell polarization

Previous studies revealed the abnormal lymphocytes subsets in IgA nephropathy (IgAN). Recently, emerging studies indicate that microRNA could influence the balance of T helper differentiation and function. Here we explore the underlying mechanism regarding how miRNA regulated lymphocytes subsets in IgAN, focused on T helper cell polarization. miRNA and mRNA profiles in peripheral blood mononuclear lymphocytes (PBMC) from 5 biopsy proven IgAN patients and 4 healthy controls were determined by next-generation sequencing and gene expression array. The differentially expressed miRNA and mRNA were conbined analyzed later.