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A Facile Three-Component One-Pot Synthesis of Structurally Constrained Tetrahydrofurans That Are t-RNA Synthetase Inhibitor Analogues

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/A_Facile_Three_Component_One_Pot_Synthesis_of_Structurally_Constrained_Tetrahydrofurans_That_Are_t_RNA_Synthetase_Inhibitor_Analogues/3332944
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资源简介:
A one-pot procedure for the efficient synthesis of tRNA inhibitor analogues was developed. Thus, three-component 1,3-dipolar cycloaddition reactions of carbonyl ylides derived from diazoindan-1,3-dione and aldehydes with other dipolarophiles in 1,1,2,2-tetrachloroethane in 80 °C gave ring-fused tetrahydrofurans having three stereocenters in good yield.
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2004-07-09
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