Tumours and Lifespan in Rats After Treatment with Chemicals

Purpose: To evaluate the induction or promotion effect of inhalation (or injection) alone and together with -naphthoflavone as promotor.

Status: 1977 - 1985, terminated; data in ERAD

Treatment: Various chemicals inhaled or injected as indicated on the table

Dosimetry: Amounts inhaled or injected

Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology

Animal: Male Sprague-Dawley SPF rats at an age of 3 months; for untreated controls see 02.01, controls treated with BNF only see 02.04

Results: By way of varying both the concentration of the product studied and the amount of BNF injected, combined dose-effect relationships can be revealed. Both factors together determine the extent of the synergistic effect.