PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 4).
收藏Protein Data Bank Japan2024-04-10 更新2026-04-25 收录
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PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 4). Descriptor: (2S)-N~1~-[(4P)-2-tert-butyl-4'-methyl[4,5'-bi-1,3-thiazol]-2'-yl]pyrrolidine-1,2-dicarboxamide, 2-({(1R)-1-[2-(4,4-dimethylpiperidin-1-yl)-3,6-dimethyl-4-oxo-4H-1-benzopyran-8-yl]ethyl}amino)benzoic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... Authors: Gunn, R.J, Lawson, J.D. Deposit date: 2023-12-05 Release date: 2024-03-20 Last modified: 2024-04-10 Method: X-RAY DIFFRACTION (3.58 Å) Cite: Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3K alpha Mutant Protein. J.Med.Chem., 67, 2024
创建时间：
2023-12-05
