Data from: Dominance reversals and the maintenance of genetic variation

Beneficial reversals of dominance reduce the costs of genetic trade-offs
and can enable selection to maintain genetic variation for fitness.
Beneficial dominance reversals are characterized by the beneficial allele
for a given context (e.g. habitat, developmental stage, trait, or sex)
being dominant in that context but recessive where deleterious. This
context-dependence at least partially mitigates the fitness consequence of
heterozygotes carrying one non-beneficial allele for their context and can
result in balancing selection that maintains alternative alleles.
Dominance reversals are theoretically plausible and are supported by
mounting empirical evidence. Here we highlight the importance of
beneficial dominance reversals as a mechanism for the mitigation of
genetic conflict and review the theory and empirical evidence for them. We
identify some areas in need of further research and development and
outline three methods (dominance ordination, allele-specific expression,
and allele-specific ATAC-Seq) that could facilitate the identification of
antagonistic genetic variation. There is ample scope for the development
of new empirical methods as well as reanalysis of existing data through
the lens of dominance reversals. A greater focus on this topic will expand
our understanding of the mechanisms that resolve genetic conflict and
whether they maintain genetic variation.