Metabolic abnormalities of the cortico-striato-thalamo-cortical circuit of rats with tic disorder

Tic disorder(TD) is a developmental neuropsychiatric disorder that mainlyoccurs duringchildhood, with significant impacts on the quality of life and psychosocial function of patients. The pathogenesisof TD involves the dysregulation of the cortico-striato-thalamo-cortical(CSTC) circuit, and metabolicabnormalities may play an important role. This study aimsto detect and analysethe metabolicabnormalities in the CSTC circuit inTD, providing areference value for the study of the pathogenesis. Ten male Wistar rats were randomly divided into the control(CK) group(n=5) and the TD group(n=5). Each rat received a daily intraperitoneal injection of 0.9% saline or 3,3’-Iminodipropionitrile(IDPN) for seven consecutive days. Tissues were collected from the striatum and cortex, and Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry was used to measure metabolite concentrations in the brain tissue samples.