Votucalis data_Frontiers in Pharmacology_2022

This data underlay findings included in "Votucalis, a Novel Centrally Sparing Histamine-binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice" accepted for publication in Frontiers in Pharmacology.The study explored novel refractory therapeutic indications based on scavenging of peripherally released endogenous histamine by Votucalis and focused on mouse models of acute itch and chronic neuropathic pain. Our overall findings further emphasise the key role for histamine in the regulation of histaminergic itch and chronic neuropathic pain.

本数据集包含了发表在《Frontiers in Pharmacology》上的文章《Votucalis，一种新型的中枢保护性组胺结合蛋白，减轻小鼠的组胺介导的瘙痒和神经性疼痛》的研究成果。该研究探讨了基于Votucalis清除周围释放的内源性组胺的新型难治性治疗指征，并聚焦于急性瘙痒和慢性神经性疼痛的小鼠模型。我们的总体发现进一步强调了组胺在调节组胺介导的瘙痒和慢性神经性疼痛中的关键作用。