High-resolution cryo-EM structures of a protein pore reveal diverse roles of membrane lipids

The data contain: 1. maps and models of the octameric pore of the wild-type Fav (wtFav) protein formed on liposomes composed of DOPC:sphingomyelin 1:1 (DOPCsm), DOPC:sphingomyelin:cholesterol 1:1:1 (DOPCsmCH) and POPG:sphingomyelin:cholesterol (POPGsmCH). 2. map of the octameric pore of the wild-type Fav (wtFav) protein formed on nanodiscs (nanoDIsc) composed of DOPC:sphingomyelin:cholesterol 1:1:1 (DOPCsmCH). 3. Crystallographic files related to X-ray structure of the truncated wild-type Fav protein: five files starting with d53Fav.