Analysis of selected DUB expression in a large case collection of NSCLCs.

Correlation between DUB expression and clinico-pathological parameters in NSCLCs. Expression was measured by ISH-TMA (Negative (NEG), ISH score≤1; Positive (POS), ISH score>1). P-values were measured by Fisher's exact test (Pearson Chi Square was used when three or more parameters were considered). Note that the number of scored cases is lower than the total number of cases since: i) cores that gave a low β-actin signal in the control hybridization (see Methods) were excluded from further consideration; ii) in some cases, individual cores detached from the slides during the manipulations; iii) complete clinical information was not available for all patients. Histotypes: AC, adenocarcinoma; SCC, squamous cell carcinoma. In tumor tissues, the ISH signals were associated with the tumor cell component and not with the adjacent or infiltrating stroma.