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DNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE208759
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To investigate the cooperative function DNMTs in the maintenance of DNA methylation at the ICRs, we established mutant ES clones lacking three major DNA methyltransferases (DNMTs). We performed WGBS for a series of D1911 mouse embryonic stem cells: wildtype (WT),DNMT1 knockout,UHRF1 knockout, DNMT3A and DNMT3B double knockout (DKO), DNMT triple knockout (TKO), We perform WGS with the 129SvEv maouse tail DNA.
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2022-10-22
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