Rh(III)-Catalyzed Atroposelective C–H Iodination of 1‑Aryl Isoquinolines

The rhodium-catalyzed enantioselective
C–H iodination
of
1-aryl isoquinolines under mild conditions is disclosed. Direct C–H
iodination of 1-aryl isoquinolines with N-iodosuccinimide
(NIS) catalyzed by chiral CpRh(III) complexes afforded a series of
axially chiral biaryl iodides in excellent yields and enantioselectivity
(up to 99% yield and 97% ee). Furthermore, the atroposelective C–H
bromination and chlorination reactions were also compatible. Notably,
the axially chiral biaryl iodides could be easily transformed to QUINAP-type
and N,N-type chiral ligands.