Effects of CXCR2 knockdown in gastric granulocytic myeloid-derived suppressor cells (G-MDSCs) during chronic inflamation.. Effects of CXCR2 knockdown in gastric granulocytic myeloid-derived suppressor cells (G-MDSCs) during chronic inflamation.

Myeloid-derived suppressor cells (MDSCs) comprise a hetergenous immune cell population that expands within the inflamed microenvironment of the stomach during pre-cancerous and cancerous lesion development in mouse. This study compares gastric CD11b+Ly6G+ cells vetween Cxcr2flox/flox and S100A8CreCxcr2flox/flox after 6 month H. felis infection. Overall design: Two mice and two knockdown conditions for four samples and 2 biological replicates per genotype.