Cardiac myosin autoantibodies promote a fibrotic transcriptome and poor outcomes in human autoimmune myocarditis

Cardiac myosin autoantibodies are known to arise in myocarditis patients and are associated with poor outcomes. Previous studies have demonstrated mechanistic links between cardiac myosin autoantibodies and cardiac damage. In this study, we tested the hypothesis that human cardiac myosin autoantibodies can directly induce fibrosis on cardiomyocytes.