Investigation of ripk3-dependent IAV-induced genes. Mus musculus

Ripk3-deficient fibroblasts and lung epithelial cells are resistant to influenza-induced cell deaths. However, Ripk3 is required for protection against influenza infection in vivo. Here, we examine the influenza-regulated gene expressions between wild type and knock out MEFs as well as an involvement of kinase activity if any. Overall design: Ripk3-/- or Ripk3+/+ MEFs treated with inhibitor of RIPK3 infected with PR8-ΔNS1 virus