Data of study "Lateral septum neurons that disable sociability in an autism mouse model

Data of study "Lateral septum neurons that disable sociability in an autism mouse model" Authors: Borie and colleagues contact information [e-mail] Orcid 0000-0002-9606-2892 institut de genomique fonctionnelle 141 rue de la Cardonille 34090 Montpellier France Description of data presented by main figures ***Calcium activity in SST neurons of LS during social behavor Figure 1D*** data of photometry ***Area under spikes of knockout model Figure 1E*** data of in vivo photometry ***Spike duration of knockout model Figure 1F*** data of in vivo photometry ***Proportion of SST neurons in LS expressing c-FOS in Magel2 KO mice Figure 1G*** data of histology ***Optogenetic inhibition of SST neurons in LS of knockout model restored social discrimination Figure 1I*** data of mouse behavior *** Injection of SSTR antagonist in LS of knockout model restored social discrimination Figure 1K*** data of mouse behavior ***Injection of SST in LS of WT mice restored social discrimination Figure 1L*** data of mouse behavior ***Proportion of SST neurons in LS expressing OXTR in Magel2 KO mice Figure 2B*** data of histology ***Density of SST neurons in LS of Magel2 KO mice Figure 2C*** data of histology ***Frequency of action potential in LS neurons inhibited by AVP then TGOT in WT mice Figure 2E*** data of electrophysiology ex vivo ***Frequency of action potential in LS neurons inhibited by AVP and TGOT in Magel2KO mice Figure 2F*** data of electrophysiology ex vivo ***Proportion of SST neurons insensitive to AVP and TGOT Figure 2G*** data of histology ***Frequency of action potential in LS neurons inhibited by AVP with GABAzine Figure 2J*** data of electrophysiology ex vivo ***Frequency of action potential in LS neurons inhibited by TGOT with GABAzine Figure 2K*** data of electrophysiology ex vivo ***Pharmacological inhibition of AVPR and OXTR during social novelty in Magel2 WT mice Figure 3A*** data of mouse behavior ***Effect of inhibitors injected during social novelty on the proportion of SST neurons with cFOS after social discrimination Figure 3C*** data of histology ***Pharmacological inhibition of AVPR and OXTR during social habituation in Magel2 WT mice Figure 3D*** data of mouse behavior ***Effect of inhibitors injected during social habituation on the proportion of SST neurons with cFOS after social discrimination Figure 3F*** data of histology ***Co-injection of AVP with antagonist of AVPR and OXTR in Magel2 KO mice Figure 3G*** data of mouse behavior ***Area under spikes in OXT neurons of PVN of WT mice Figure 4C*** data of in vivo photometry ***Proportion of OXT neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4E*** data of histology ***Area under spikes in AVP neurons of PVN of WT mice Figure 4H*** data of in vivo photometry ***Proportion of AVP neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4J*** data of histology ***Optogenetic inhibition of oxytocinergic or vasopressinergic PVN-LS pathways in Avp-CRE or OXT-Cre mice Figure 5B*** data of mouse behavior ***Optogenetic inhibition of oxytocinergic or vasopressinergic SON-LS pathways in Avp-CRE or OXT-Cre mice Figure 5D*** data of mouse behavior ***Optogenetic activation of oxytocinergic or vasopressinergic PVN-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5F*** data of mouse behavior ***Optogenetic activation of oxytocinergic or vasopressinergic SON-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5H*** data of mouse behavior