ROLE OF STATINS ON CARDIAC REMODELING IN HEART FAILURE: A SYSTEMATIC REVIEW

Heart Failure is a chronic condition in which the heart doesnt pump blood as well as it should it is a major cause of morbidity and mortalityglobally.Heart failure is the pathophysiologic state in which the heart, via an abnormality of cardiac function (detectable or not), fails to pump blood at a rate commensurate with the requirements of the metabolizing tissues or is able to do so only with an elevated diastolic filling pressure. As recent studies describe Statins to have a beneficial role in preventing Cardiac remodeling in Heart Failure, this systematic review aims to explore the use of Statins as a potential therapy in patients with Heart Failure. This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)2020 guidelines. The search was conducted using PubMed, PubMed Central, Google Scholar in July 2023. The inclusion criteria were set to free full-text articles published within 5 years, human studies, literature reviews, systematic reviews, meta -analyses, observational studies, RCTs, studies investigating adult samples, and the English language. Exclusion criteria included animal studies, posters, editorials. The primary search yielded18,166 studies, which were screened and subsequently assessed through quality appraisal tools respective to each study. The result of this review demonstrated that statins prevent cardiac remodeling in heart failure. In the end, both randomized and nonrandomized clinical trails are necessary for more conclusive findings.