Pain output from wet lab experiment (Wilson et al) and three models.

Cells are shaded to indicate relative change of that individual cell from the “Intact” value found with intact PKCδ and SOM signaling (i.e. no inhibition). Dark green is an analgesic effect compared to intact condition and light green is a small analgesic effect compared to intact. Dark orange is a hyperalgesic effect compared to intact. No shading represents a lack of significant change from the intact value. Intact values from Wilson et al[16] are reported from two separate experiments labeled as “PKCδ exp” and “SOM exp”.