Integration of whole-genome DNA methylation data with RNA sequencing data to identify markers for bull fertility

Predicting dairy bull fertility is a current challenge for the dairy industry. The goal of this study was to integrate DNA methylation data with previously published RNA sequencing results in order to identify candidate markers for sire fertility. Overall design: Five high-fertility bulls and five low-fertility bulls were used for this study. Sperm samples were subjected to DNA extraction and subsequent whole-genome bisulfite sequencing.