In CRISPR-Cas9 systems, It is a challenge to achieve effective homology-directed repair (HDR) in organisms that proficiently employ non-homologous end joining (NHEJ) to fix DNA double-strand breaks (D

NIAID Data Ecosystem60

Data_Sheet_2_Systematic Prediction of Antifungal Drug Synergy by Chemogenomic Screening in Saccharomyces cerevisiae.ZIP

抗真菌药物

化学基因组学

Since the earliest days of using natural remedies, combining therapies for disease treatment has been standard practice. Combination treatments exhibit synergistic effects, broadly defined as a greate

NIAID Data Ecosystem40

Predicting kinase inhibitors using bioactivity matrix derived informer sets

激酶抑制剂

化学基因组学

Prediction of compounds that are active against a desired biological target is a common step in drug discovery efforts. Virtual screening methods seek some active-enriched fraction of a library for ex

NIAID Data Ecosystem70

Chemical Genomics Profiling of Antimalarial Drugs

抗疟药物机制研究

化学基因组学

Chemical Genomics Profiling is based on the premise that diploid yeast containing a gene expressed in heterozygosis will become hypersensitive to sub-lethal doses of an inhibitor targeting the product

NIAID Data Ecosystem60

MOESM2 of Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

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