UBTF tandem duplication AMLs are sensitive to menin inhibition

To investigate the effect of Menin inhibitor on UBTF-TD harboring AML. We characterized UBTF-TD interaction with KMT2A and Menin in different leukemia models including KMT2A-r, transduced and normal cbCD34+ cells as well as in primary AML cells with UBTF-TD mutation. We also analized gene expression pattern upon treatment with Menin inhibitor. Comparative gene expression profiling analysis of RNA-seq data for patient-derived UBTF-TD AML cells after treatment with Menin inhibitor (SNDX-5613/Revumenib).