Sel1L-Hrd1 ERAD is required for the maintainenance of beta cell identity and function
收藏NIAID Data Ecosystem2026-04-30 收录
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资源简介：
Mice with Sel1L deficient beta cells develop severe hyperglycemia, glucose intolerance and impaired insulin secretion. Using single cell sequencing, we identified that Sel1L plays a major role in maintaining beta cell maturation by suppressing TGF-beta signaling. Overall design: Islets were isolated from 5 weeks old Sel1Lf/f and Sel1LIns1 mice and following overnight recovery, trypsinized to obtain single cell suspension and processed using 10X Genomics CHROMIUM single cell 3' solution.
创建时间：
2022-11-11
