TET1 regulates reprogramming with Vitamin C and relatively small molecules. TET1 regulates reprogramming with Vitamin C and relatively small molecules

We found a small molecule-DKG, relative to Vitamin C, could replace the function of Viamin C during reprogramming. After comparing transcriptome profiling (RNA-seq) of this molecule to vitamin C, it could provide a framework for more mechanism. Overall design: mRNA profiles of day 3 and day8 during reprogramming with DMSO or Vitamin C or DKG infected Flag or Tet1CD virus.