five

Bulk RNASeq S64F MAFA male islets

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP591092
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Mice harboring the S64F mutation in the endogenous MafA gene ("Het") on a mixed genetic background (SJL x C57/Bl6J) show impaired glucose tolerance then overt diabetes by 5 weeks of age. Moreover, when backcrossed to the C57/Bl6J background, mutant Het mice are euglycemic similar to their wild type littermates, suggesting compensation which can prevent diabetes. Overall design: Male mouse islets isolated at 5.5 weeks of age and submitted for sequencing. Each sample was produced from islets from one unique mouse
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2025-12-01
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