Biodistribution of mesenchymal stromal cells labeled with [89Zr]Zr-oxine in local radiation injuries in laboratory animals

Tracking the migration pathways of living cells after their introduction into the patient's body is a topical issue in the field of cell therapy. The question of studying the possibility of intravital long-term biodistribution of mesenchymal stromal cells in the body remains open today.
The study used 49 laboratory animals. Modeling of local radiation injuries was carried out and the distribution dynamics of mesenchymal stromal cells labeled with [89Zr]Zr-oxin in the body of rats was studied.
The use of intravenous administration of mesenchymal stromal cells of human mucosal tissue labeled with [89Zr]Zr-oxin makes it possible to visualize the focus of local radiation injury using positron emission tomography, and for effective cell therapy, local injection of mesenchymal stromal cells into the area of the visualized focus of local radiation injury is recommended.
Biodistribution of human mesenchymal stromal cells labeled with [89Zr]Zr-oxin is completely safe, since intravenous administration leads to an initial accumulation of cells in the lungs with subsequent redistribution to the liver, spleen and kidneys; with intracardiac administration, the distribution of cells is similar to intravenous administration; when locally injected into tissues, cells of mesenchymal stromal cells are not distributed systemically in significant quantities.