Effect of RGRN-305 on MC903-induced skin inflammation in mice

The aim was to demonstrate that RGRN-305 suppresses MC903-induced atopic dermatitis like-alterations in gene expression. Overall design: Mice were challenged with MC903 or vehicle on right ears of mice followed by treatment with RGRN-305 or dexamethasone daily for 9 days. Ear biopsies were collected at the end of the experiment (day 9) and RNA sequenced (gene expression analysis). Number of mice in treatment groups: vehicle = 6, MC903 =8, MC903+RGRN-305 = 8, MC903+Dexamethasone = 4.