Recurrently mutated enzymes in the nine cancer types.

(A) The 96 metabolic genes that are recurrently mutated in samples (≥ 5%). The functional pathways in the grey box denote enriched pathways among the 96 genes (Hypergeometric, P B) The selected 20 metabolic genes that are recurrently mutated in samples (≥ 5%), and are expected to have a significant functional impact from their genomic sequence mutations in any of nine cancer types. Blue box: recurrently mutated genes for GoF analysis (gene having missense mutations). Red box: recurrently mutated genes for LoF analysis (genes having nonsense, frame shift indels, splice site indels&SNP mutations).