Pharmacologic C5aR1 antagonism in the Arctic mouse model of Alzheimer's disease modifies microglial polarization and astrocyte signaling
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP455344
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资源简介：
SC and SN RNA-seq reveal that pharmacologic inhibition of C5aR1 both suppresses disease enhancing processes and promotes disease mitigating pathways in an AD mouse model. Overall design: The Arctic model of Alzheimer's disease and wildtype mice were treated with a C5aR1 antagonist (PMX205) or not for 12 weeks. Hippocampi were dissect and processed for single cell and single nucleus RNA-sequencing
创建时间：
2024-08-30
