FGFR1c and Klotho ligand binding and activation

FGF23 is a member of the endocrine subfamily of FGFs. It is produced in bone tissue and regulates kidney functions. Klotho is essential for endogenous FGF23 function as it converts FGFR1c into a specific FGF23 receptor.FGF23属于FGFs内分泌亚家族，由骨骼组织产生，并调节肾脏功能。Klotho对于内源性FGF23功能的发挥至关重要，因为它将FGFR1c转化为特定的FGF23受体。