Genome-wide transcriptome analysis of the ovaries in different sheep. Genome-wide transcriptome analysis of the ovaries in different sheep

We performed a genome-wide analysis of mRNAs and lncRNAs from Small Tail Han sheep of genotypes FecBBFecBB (Han BB) and FecB+ FecB+ (Han++) and from Dorset sheep (Dorset) to identify potential regulators of fecundity. An integrated analysis revealed significantly correlated patterns of expression. Dramatic changes of mRNAs and lncRNAs suggest their critical roles in sheep fecundity. This study provides a novel view of the regulatory mechanisms involved in sheep fecundity. Overall design: Ovary transcritomic profiles of different sheep were generated by RNA-Seq, in triplicate, using Illumina HiSeq 2000.