Expression analysis of AR-positive, ER-/PR-negative breast cancer and normal tissues

This study is intended to investigate the differences in biological molecular expression upon HER2 status (HER2-positive and –negative) in AR-positive, ER-/PR-negative breast cancer. Results indicate that differentially expressed genes were involved in olfactory transduction, major histocompatibility complex, ECM-receptor interaction, focal adhesion, adherens junction, as well as protein processing in endoplasmic reticulum. A total of 9 samples are analyzed. Of which, 3 samples (T39, T40 and T54) were AR-positive, ER-/PR-negative, HER2-positive breast cancer, and 3 samples (B13, B29 and B32) were AR-positive, ER-/PR-negative, HER2-negative breast cancer, and other 3 samples were normal breast tissues. The three normal breast samples (N39, N40 and N54) were used for gene expression analysis as a reference group.