Gold nanoparticles produced by laser ablation in liquids for diagnostic imaging improvements

Pulsed Nd:YAG laser at $10^10$ W/c$m^2$ intensity was employed to induce gold ablation in liquids. Gold nanoparticles are generated with 10-100 nm size and different solution concentrations. Nanoparticles were characterized using different physical analyses (optical spectroscopy, SEM, TEM, XRF,…). The solution was monitored through optical transmission spectroscopy in the visible wavelength range at concentrations from 1 mg/ml to 100 mg/ml. Surface plasmon absorption resonance was investigated. The biocompatible solution was injected by Biologists in living mice in order to control the organs uptake and decay by using 45 keV X-rays imaging. The increment of the contrast imaging was investigated and measurements and theoretical aspects are present and discussed.