Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 21

Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 21 Descriptor: 4-[4-[bis(fluoranyl)methoxy]phenyl]-3-cyclopropyl-6-(2-methylindazol-5-yl)-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 Authors: Schimpl, M. Deposit date: 2023-08-30 Release date: 2024-03-20 Last modified: 2024-04-10 Method: X-RAY DIFFRACTION (1.109 Å) Cite: Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024