Regio- and Enantioselective Nickel-Catalyzed Ipso- and Remote Hydroamination Utilizing Organic Azides as Amino Sources for the Synthesis of Primary Amines

Primary amines serve as key synthetic precursors to most other N-containing compounds, which are important in organic and medicinal chemistry. Herein, we present a NiH-catalyzed mild ipso- and remote hydroamination technique that utilizes organic azides as deprotectable primary amine sources. This strategy offers a highly flexible platform for the efficient construction of α-chiral branched primary amines, as well as linear primary amines.