A BDNF-TrkB autocrine loop enhances senescent cell viability [scRNA-seq]

We used single cell RNA sequencing (scRNA-seq) to investigate the RNA expression correlation between BDNF and STAT3-associated targets in etoposide-treated human fibroblast cell populations. Overall design: Proliferating human fibroblasts (WI-38 cells) were treated with etoposide to trigger senescent-like phenotypes. Cells were trypsinized, washed and then subjected to scRNA-seq experiment.