RNA sequencing of a Spinocerebellar ataxia type 3 (SCA3) mouse model containing the full human ATXN3 gene with a repeat expansion of 75-80 CAGs I

Name: RNA sequencing of a Spinocerebellar ataxia type 3 (SCA3) mouse model containing the full human ATXN3 gene with a repeat expansion of 75-80 CAGs I
Creator: LUMC
Published: 2022-02-20T00:00:00+08:00

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

神经退行性疾病

基因表达分析

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http://data.iscr.ac.cn/Article?id=ebcefbb2e1206b22bdefe5c9a00454e7 数据链接链接失效反馈

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资源简介：

We have performed RNA sequencing analysis of brain tissue and blood from the MJD84.2 mouse model for SCA3 (described by Cemal et al, Human molecular genetics 2002, 11:1075-1094). Mice were 17.5 months of age at sacrifice and brainstem, cerebellum, cortex and striatum were sequenced. Transgenic SCA3 mice showed most transcriptional changes in striatum and brainstem. Axon guidance, synaptic transmission, pi-3k cascade and cholesterol biosynthesis pathways are implicated to be affected based on the transcriptional changes.

提供机构：

LUMC

创建时间：

2022-02-20