NPR1

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

瓜酰基环化酶，催化GTP生成cGMP，可分为可溶性形式和膜形式（Garbers和Lowe，1994 [PubMed 7982997]）。膜型瓜酰基环化酶，通常被称为A至F型的瓜酰基环化酶，构成一类具有相似拓扑结构的细胞表面受体：一个细胞外配体结合域、一个单一的跨膜结构域以及一个包含蛋白激酶样结构和环化酶催化结构的细胞内区域。GC-A和GC-B作为利尿肽的受体；它们也被称为心房利尿肽受体A（NPR1）和类型B（NPR2；MIM 108961）。此外，参见NPR3（MIM 108962），它编码的蛋白质仅具有配体结合的跨膜结构和37个氨基酸的细胞质结构域。NPR1是一种膜结合的瓜酰基环化酶，作为心房和脑利尿肽（ANP（MIM 108780）和BNP（MIM 600295））的受体。[由OMIM提供，2009年5月]