Transcriptome profiles of wild-type, IRF8KO microglia

The lineage-determining transcription factor IRF8's function in microglia is unclear. Our study aims to shed light on this by analyzing the genome-wide, temporal transcriptome profiles of wild-type and IRF8KO microglia. We used deep-sequencing and differential analysis to identify the effects of IRF8 on transcription programs in microglia, such as microglia identity gene expression. This study provides a new understanding of the transcriptional programs in microglia. Transcriptome profiles of WT and IRF8KO microglia were analyzed.谱系决定转录因子干扰素调节因子8（IRF8）在小胶质细胞中的功能尚不明确。本研究旨在阐明该问题，通过分析野生型（WT）与IRF8基因敲除（IRF8KO）小胶质细胞的全基因组时序转录组谱。我们采用深度测序与差异分析方法，鉴定IRF8对小胶质细胞转录程序的调控效应，例如小胶质细胞特征基因的表达模式。本研究为解析小胶质细胞的转录程序提供了全新视角。本研究对野生型与IRF8基因敲除小胶质细胞的转录组谱进行了分析。