MERS-CoV transcriptomic consensome - full

This network ranks human genes by the significance of their differential expression (p < 0.05) across multiple independent public archived experiments involving infection of human cells by MERS.
For an introduction to consensome analysis please refer to Ochsner et al. (2019) Nat Sci Data 6, 252
METHODS
The frequency of differential expression (p < 0.05) of human gene targets (discovery rate) was calculated across publicly archived transcriptomic experiments involving infection of a human cell line with different viruses. The consensome p-value (and FDR-corrected q-value) correspond to the probability that this frequency is a random event. Genes are ranked in ascending order of consensome q-value and organized into percentiles, such that the 99th percentile contains the genes with the lowest consensome q-value. The higher the percentile, the greater the confidence of a transcriptional regulatory relationship between CoV infection and a target gene.
INTERPRETATION
Viral transcriptional targets in this network are organized according to SPP’s signaling pathway node-centric classification, which classifies mammalian genes as encoding receptors, enzymes, transcription factors, ion channels or co-nodes. Target genes (circles) are colored according to the category of factor they encode: orange = receptors; blue = enzymes; green = transcription factors; mustard = ion channels; grey = co-nodes. Target genes are sorted into classes (white rectangles) of each category. Circle sizes are proportional to the PERCENTILE: the larger the circle, the lower the q-value and the greater the confidence that a gene target is regulated in response to infection by that virus. Clicking a gene target will pull up a pane showing details on the data point, including details such as the family to which it belongs, and a link to the underlying data points on the SPP website.

This network contains the full consensome data; however, for an effective visualization,  the custom sample displays only genes with a PERCENTILE value equal or greater than 95 (top 5%). The network for the 95th PERCENTILE subset only is available HERE.
DATASETS
The datasets underlying this consensome can be accessed at: https://www.signalingpathways.org/datasets/index.jsf