Neurons harbor high levels of endogenous single strand DNA breaks (SSBs) that are targeted to neuronal enhancers and correlate with marks of DNA demethylation. To determine the source of SSBs at neuro

NIAID Data Ecosystem50

Role of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RNA-seq]. Mus musculus

表观遗传重编程

DNA去甲基化机制

With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methy

NIAID Data Ecosystem30

Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency [RNA-Seq]

iPSC重编程

DNA去甲基化机制

Active DNA demethylation via Ten-eleven Translocation (TET) family enzymes is essential for epigenetic reprogramming in cell state transitions. TET enzymes catalyze up to three successive oxidations o

NIAID Data Ecosystem80

Somatic DNA demethylation generates tissue-specific methylation states and impacts flowering time [BiSulfite-seq]

DNA去甲基化机制

开花时间调控

Cytosine methylation is a reversible epigenetic modification to DNA. In plants, removal of cytosine methylation is accomplished by the four members of the DME family of 5-methylcytosine DNA glycosylas

NIAID Data Ecosystem40

Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA

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