The let-7-Imp axis regulates aging of the Drosophila testis stem cell niche.

ChEBI2012-05-31 更新2026-07-21 收录

干细胞衰老

果蝇生殖衰老调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-37041 数据链接链接失效反馈

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The let-7-Imp axis regulates aging of the Drosophila testis stem cell niche.

创建时间：

2012-05-31

Single Cell RNA-Sequencing using smart-seq2 of young and old murine hematopoietic stem cells

干细胞衰老

单细胞转录组学

Ageing of the hematopoietic stem cell (HSC) compartment is characterized by skewing towards the myeloid lineage and reduced stem cell function, the molecular basis of which is largely unknown. Using s

NIAID Data Ecosystem150

Aged Hematopoietic Stem Cells Drive Aging-Associated Immune Remodeling

干细胞衰老

免疫系统重建

Phenotypic and functional changes seen in the aged adaptive immune system are primarily driven by aging of hematopoietic stem cells (HSCs), pharmacological rejuvenated aged HSCs were able to reconstit

NIAID Data Ecosystem30

Urbanus and Cosgrove et al. Nature Communications (2023). DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

干细胞衰老

髓系细胞生成

Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in t

NIAID Data Ecosystem30

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [ChIP-seq]

干细胞衰老

ATF4转录因子ChIP-seq

Human acute myeloid leukemia (AML) KG1a cells or mouse BM cells (mouse bone morrow cells were employed for each ChIP assay. The ChIP procedure was performed according to a previously described protoc

NIAID Data Ecosystem40

Transcription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging

干细胞衰老

转录组学分析

Transcription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging

ChEBI2008-10-20 更新30