Pro-neural transcription factor Six3 has been implicated in neuronal differentiation. We established primary neural stem cell with Six3 overexpression, and utilized CUT&RUN to profile genomic loci bou
TCQA promoted differentiation of hNSCs at least toward the neuronal lineage and suggests the possibility of using TCQA to promote neurogenesis. When differentiation is induced by growth factor withdra
Large-scale proliferation and multi-lineage differentiation capabilities make neural stem cells (NSCs) a promising renewable source of cells for therapeutic applications. However, the practical applic
During development, progenitors integrate external signaling cues to control differentiation. How combinatorial signal inputs modulate fate decisions and the underlying molecular information processin
Here we show that GemC1-deficiency in mice results in the development of severe hydrocephalus impaired cytoarchitecture and function of the SVZ neurogenic niche due to lack of mature ependymal cells.
