The functional significance of upregulation miR-34a in combination with albumin-bound paclitaxel nanoparticles in U251 glioblastoma cell line has been evaluated. The MTT assay determined that miR-34a
The ΣFIC was calculated as FIC A + FIC B where the combinations are considered synergistic when the ΣFIC value is <0.5, weakly synergistic when ΣFIC is 0.6 to 1.0, additive when ΣFIC is 1.0 to 2.0 and
The major challenges we are facing in cancer therapy with paclitaxel (PTX) are the drug resistance and severe side effects. Massive efforts have been made to overcome these clinical challenges by comb
*HL = HAMLET. Concentration used was 100 µg/ml (6 µM). **The last column describes the concentration of HAMLET required to make each strain sensitive to the respective antibiotic.
Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a BET protein in
