Genome-wide analysis of the role of FUS in RNA polymerase II transcription. Mus musculus

FUS/TLS has been known to be components of fusion oncogenes that cause human cancers, and recent studies identified that mutations in these genes have been implicated in amyotrophic lateral sclerosis (ALS). To analyze an effect of FUS on RNA polymerase II activity, we performed ChIP-seq analysis of RNA polymerase II using 8WG16 At-pol II Ab in FUS-knocked down N2A cells.