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Related Article from Molecular Targeting of Neural Cancer Stem Cells: TTAGGG, You're It!

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Related Article from Molecular Targeting of Neural Cancer Stem Cells: TTAGGG, You're It!

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2011-01-01

腺癌干细胞

靶向治疗

Pancreatic cancer remains one of the most aggressive and lethal cancers in humans. It is undeniably known for its notorious resistance to conventional chemotherapeutics which are often associated with

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Additional file 1 of Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report

癌症基因组数据

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Additional file 1: Supplementary Table 1. Target genes of the comprehensive genomic analysis.

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Supplementary Table SI from Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216

靶向治疗

药物筛选

Supplementary Table SI XLS file 19K, Supplementary Table SI: Kinase selectivity of PF-4989216

aacr.figshare.com2023-05-31 更新50

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [ChIP-seq]. Homo sapiens

癌症表观遗传学

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The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types1. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, sugges

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Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling

肿瘤分子机制

靶向治疗

Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked

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Related Article from Molecular Targeting of Neural Cancer Stem Cells: TTAGGG, You're It!

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