Simulation of the effect of mutation rate and environmental factors on the incidence of neoplasm in an individual.

As a continuation of Table 1, an individual was assumed to have an incidence of 60,000 cells with in his life time. These cells were assumed to be in senescent stages () with slight proliferation potential (). Different mutational rates, 1 (1m/g) or 2 (2m/g) per generation, and varying environmental stimulations, or were used to investigate the incidence of escape from senescence and development of different sizes of masses by each of 60,000 cells. Exposure times to chronic stimulation were 6 months every year (Table 2) or all year around (Table 3). Simulations are run for a period of 1 year. Outcome of 60,000 cells with under hormonal exposure for 6 months.