Thyroid stimulating hormone (TSH) signaling

Human thyroid-stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in the regulation of the hypothalamus-pituitary-thyroid axis by stimulating production and secretion of the thyroid hormone from the thyroid gland and – on a longer time scale – growth and differentiation of thyrocytes. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2032 CPTAC Assay Portal]

人类促甲状腺激素（TSH）是一种由垂体前叶分泌的糖蛋白激素，它在调节下丘脑-垂体-甲状腺轴中发挥着至关重要的生理作用，通过刺激甲状腺激素从甲状腺的产生和分泌，以及长期尺度上的甲状腺细胞生长和分化。TSH与TSH受体结合，该受体为G蛋白偶联受体超家族的整合膜蛋白之一。TSH通过多种信号级联反应发挥作用，如cAMP级联反应和磷脂酶Cβ介导的肌醇磷脂生成。此外，它还会向NF-κB、有丝分裂激活蛋白激酶、蛋白激酶C模块发出信号。NetPath（http://www.netpath.org）是由约翰霍普金斯大学PandeyLab（http://pandeylab.igm.jhmi.edu）和生物信息学研究所（http://www.ibioinformatics.org）共同发起的合作项目。若使用此通路，请引用NetPath网站，直至通路发表。该通路上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP2032 CPTAC检测门户]进行针对性的检测。